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Struggling with tired, dull or crepey skin that hydration alone hasn’t fixed? Elite Skin Clinic offers Polynucleotide (PDRN) treatment — a regenerative injectable that works at a cellular level to repair and rejuvenate skin from within, available at our doctor-led clinic near Paddington & Marble Arch.
WHY CHOOSE POLYNUCLEOTIDE TREATMENT?
• Regenerative, Not Just Hydrating: Unlike standard skin boosters, Polynucleotides stimulate the skin’s own
repair and collagen-producing processes, rather than simply adding moisture.
• Ideal for Delicate Areas: Particularly effective for thin, fragile skin such as under the eyes, where other
injectables are less suitable.
• Doctor-Led Precision: Every treatment is delivered by a GMC-registered doctor following a full consultation.
• Minimal Downtime: Small bumps or mild redness typically settle within a day or two, with no significant
recovery time needed.
TREATMENT SUMMARY
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Treatment Time 30 minutes
Recovery / Downtime Minimal — 24–48 hours for any
mild swelling
Results Improved hydration, elasticity and
skin repair, building over 2–4 weeks
Risks Redness, swelling, bruising, small
bumps at injection sites
Anaesthetic Topical numbing cream available
Specialist GMC-registered doctor
Results Duration 6 months+, maintained with
periodic sessions
How Many Treatments Course of 2–3 sessions, 2–4 weeks apart
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POLYNUCLEOTIDE TREATMENTS
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are naturally derived molecules, most commonly sourced from purified salmon DNA, with a long history of use in regenerative medicine — originally in wound healing — before being adapted for aesthetic use.
Injected into the skin, they stimulate fibroblast activity (the cells responsible for producing collagen and elastin), improve hydration, and support the skin’s natural repair processes. Unlike dermal fillers, Polynucleotides don’t add volume. Unlike traditional skin boosters, their mechanism is
regenerative rather than purely hydrating.
WHAT DO POLYNUCLEOTIDES TREAT?
• Under-eye hollowing, dark circles and thin, crepey under-eye skin
• Overall skin dullness, dehydration and loss of elasticity
• Early signs of ageing, particularly in areas with thinner skin
• Skin recovering from previous treatments, sun damage, or acne scarring
• Neck and décolletage rejuvenation
• Post-procedure skin support
Polynucleotide vs. Profhilo: Which is Right for You?
Both are injectable skin-quality treatments, but they work differently. Profhilo is a high-concentration stabilised hyaluronic acid treatment, focused on deep hydration and stimulating collagen/elastin through tissue hydration — best suited to broader areas of the face and neck.
Polynucleotides work through a regenerative mechanism, supporting cellular repair and fibroblast activity directly, and are particularly well-suited to more fragile or thin skin, such as the under-eye area, where Profhilo is less commonly used.
Many patients combine both as part of a broader skin health plan — Polynucleotides for regeneration in delicate areas, Profhilo for overall hydration elsewhere on the face. Consider your specific concern and consult with our doctors at
Elite Skin Clinic to find the best option for your needs.
HOW DOES THE TREATMENT WORK ?
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Your treatment begins with a full consultation with one of our GMC-registered doctors, who will assess your skin and confirm whether Polynucleotides are the right treatment for your goals. A series of small injections then deliver the Polynucleotide solution into the targeted area — most commonly the under-eye area, cheeks, neck or décolletage. The treatment takes around 30 minutes, with topical numbing cream available for comfort.
FREQUENTLY ASKED QUESTIONS
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Are Polynucleotides safe? Polynucleotides have a long history of medical use in wound healing and tissue repair, and are considered well-tolerated when administered by a trained medical professional.
Do Polynucleotide injections hurt? Most patients describe mild discomfort, similar to other fine-needle injectable treatments. Topical numbing cream is available for comfort.
How many sessions will I need? Most patients benefit from a course of 2–3 sessions spaced 2–4 weeks apart, followed by maintenance sessions roughly every 6 months.
Can Polynucleotides be combined with other treatments? Yes — commonly combined with Profhilo, dermal filler, or anti-wrinkle injections as part of a broader treatment plan, depending on your goals.
Is there any downtime? Minimal — mild swelling or small bumps at injection sites typically settle within a day or two.
Who shouldn’t have Polynucleotide treatment? Patients with a known fish allergy, pregnant or breastfeeding patients, or those with active skin infections in the treatment area should not proceed without further medical assessment.
Save Big: Polynucleotide Treatments in London!
Polynucleotide Treatment for face starts from £219
Polynucleotide Treatment for eyes starts from £199
PRE-CARE AND AFTER-CARE FOR POLYNUCLEOTIDE TREATMENT
Pre-Care: 1. Stay well hydrated in the days before treatment. 2. Avoid blood-thinning medication or supplements (aspirin, ibuprofen, fish oil) for about a week beforehand, if medically appropriate. 3. Have a thorough consultation to
discuss medical history, including any fish allergy, given the biological origin of the product.
After-Care: 1. Avoid touching or applying makeup to the treated area for a few hours. 2. Avoid saunas, steam rooms
and intense exercise for 24–48 hours. 3. Mild redness or small bumps typically settle within a day or two. 4. Stay
hydrated and use daily SPF to support and prolong results.
Why Choose Elite Skin for Polynucleotides
Elite Skin Clinic is a doctor-led aesthetic clinic based at Marble Arch Medical Centre, London W2. Every Polynucleotide treatment is delivered by a GMC-registered doctor following a full consultation — never a walk-in, beautician-led, or nurse-only appointment. If Polynucleotides aren’t the right fit for your goals, we’ll tell you, and recommend what would serve you better instead.
If you’d like more information about our features, get in touch today.
