Polynucleotides Cost in London 2026: Prices, Sessions & Results

Polynucleotides have quickly become one of the most talked-about skin treatments in the UK, especially for tired, thin skin under the eyes. If you are considering them, the first question is usually: how much do polynucleotides cost in London, and is it worth it? This guide explains typical London prices, what affects the cost, how many sessions you need and what results to expect, so you can make an informed decision.

At EliteSkin, a doctor-led clinic at Marble Arch Medical Centre near Paddington, polynucleotides treatment starts from £199 for the under-eye area and £219 for the face, carried out by GMC-registered doctors.

What are polynucleotides?

Polynucleotides, also called PDRN or salmon DNA skin boosters, are a regenerative injectable made from highly purified DNA fragments, usually derived from salmon. Rather than adding volume like dermal filler, they work with your skin's own repair processes, supporting fibroblast activity, hydration and elasticity.

They are particularly popular for areas where skin is thin and delicate, such as:

• Under the eyes, for crepey skin, fine lines and a tired look

• The face, for overall skin quality, texture and glow

• The neck and décolletage, for crepey skin and fine lines

How much do polynucleotides cost in London?

In London, polynucleotides typically cost from around £200 to £400 or more per session, depending on the clinic, the treatment area and who carries out the treatment. Because a course of sessions is usually recommended, it is worth looking at the total cost of the course rather than the price of a single session.

EliteSkin prices (per session):

• Under-eyes: from £199

• Face: from £219

• Consultation: free, with a GMC-registered doctor

Your doctor will confirm the number of sessions and the total course price at your consultation, based on your skin and goals.

What affects the price?

• Treatment area: the under-eyes, face and neck need different amounts of product and time.

• Number of sessions: most people need a course rather than a single treatment.

• Who treats you: doctor-led treatment usually costs more than non-medical providers, but offers medical assessment and safer management if anything unexpected happens.

• The product used: established, licensed polynucleotide products cost clinics more than unbranded alternatives.

Be cautious of prices far below the usual London range. Unusually cheap treatment can mean an unlicensed product or an injector without medical training, which matters in delicate areas like under the eyes.

How many polynucleotide sessions will I need?

Most patients benefit from a course of 2 to 3 sessions, spaced 2 to 4 weeks apart, followed by maintenance sessions roughly every 6 months. Results build gradually, because polynucleotides work by supporting your skin's natural regeneration rather than giving an instant change.

What results can I expect?

Polynucleotides are a skin-quality treatment, not a volumising one. Patients typically notice skin that looks more hydrated, smoother and firmer, with softer fine lines, particularly under the eyes. Improvement continues over the weeks after each session, so results are best judged a few weeks after completing the course. Results vary from person to person.

Polynucleotides vs Profhilo vs dermal fillers

• Polynucleotides: regenerative; best for thin, crepey skin and the delicate under-eye area.

• Profhilo: a hyaluronic acid skin booster for hydration and laxity across the face and neck. Read about Profhilo.

• Dermal fillers: add volume and structure, for example to cheeks, lips or tear troughs. Read about tear trough filler.

They can also be combined as part of a wider treatment plan. Your doctor will advise on the right option, or combination, for your skin.

Is there any downtime?

Downtime is minimal. Mild swelling or small bumps at the injection points usually settle within a day or two, and most people return to normal activities straight away.

Who should not have polynucleotides?

Polynucleotides may not be suitable if you have a known fish allergy, are pregnant or breastfeeding, or have an active skin infection in the treatment area. A full medical consultation before treatment checks this.

Frequently asked questions

How much do polynucleotides cost in London?

Typically from around £200 to £400 or more per session. At EliteSkin, under-eye treatment starts from £199 and face treatment from £219, with a free doctor consultation.

How many sessions of polynucleotides do I need?

Most patients have a course of 2 to 3 sessions, 2 to 4 weeks apart, then maintenance roughly every 6 months.

Are polynucleotides good for under-eyes?

Yes. The under-eye area is one of the most popular areas for polynucleotides, because the skin there is thin and delicate and responds well to treatments that improve skin quality.

Do polynucleotide injections hurt?

Most patients describe mild discomfort rather than pain. Topical numbing cream can be used to keep you comfortable.

Book a polynucleotides consultation near Paddington

EliteSkin is a doctor-led clinic on the 1st Floor of Marble Arch Medical Centre, 217 Edgware Road, London W2 1ES, a short walk from Paddington, Edgware Road and Marble Arch stations. Rated 4.9 stars from 461+ Google reviews, with consultations in English, Arabic, Russian and Greek.

Learn more on our polynucleotides treatment page, see our full price list, or call 020 3965 0299 to book your free consultation.